Intradermal injection of tranexamic acid combined with topical hydroquinone cream versus topical hydroquinone cream alone in the treatment of melasma

Background: Melasma is a common acquired skin disorder that presents as bilateral, blotchy, brownish facial pigmentation due to dysfunction in melanogenesis. It most people who tans easily or have naturally brown (Fitzpatrick’s phototypes III, IV). Although several treatments are currently used, it remains great challenge. Aim: This study aims compare the efficacy of intradermal injection tranexamic acid (TA) combined with topical hydroquinone cream versus (HQ) treatment melasma. Materials and Methods: In thisinterventional prospective comparative clinical trial study, 31 patients melasma were divided randomly into 2 groups, A (16 patients) B (15 patients). Group received combination intralesional cream, while group alone. Both groups assessed by MASI score at baseline weeks 2, 4, 6, 8. Results: Thirty-one 15 B) completed study. According decline score, was more effective than alone Conclusion: Injection TA intradermally HQ can be an for